COMPUTATIONAL ANALYSIS REVEALS MONOMETHYLATED TRIAZOLOPYRIMIDINE AS A NOVEL INHIBITOR OF SARS-COV-2 RNA-DEPENDENT RNA POLYMERASE (RDRP)

Computational Analysis Reveals Monomethylated Triazolopyrimidine as a Novel Inhibitor of SARS-CoV-2 RNA-Dependent RNA Polymerase (RdRp)

The human population is Aquabug / Wally / Scuba / Penguin Parts still facing appalling conditions due to several outbreaks of Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) virus.The absence of specific drugs, appropriate vaccines for mutants, and knowledge of potential therapeutic agents makes this situation more difficult.Several 1,

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Punicalagin and ellagic acid from pomegranate peel induce apoptosis and inhibits proliferation in human HepG2 hepatoma cells through targeting mitochondria

Pomegranate peel polyphenols (PPPs) extracts presented anti-proliferation and apoptosis-inducing effects in human HepG2 hepatoma cells in our previous studies.This study aimed to investigate the differential anticancer effects of main PPPs components punicalagin (PC) and ellagic acid (EA) on HepG2 cells and their possible action mechanisms.Cell pro

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Standardised practices in the networked management of congenital hyperinsulinism: a UK national collaborative consensus

Congenital hyperinsulinism (CHI) is a condition characterised by severe and recurrent hypoglycaemia in infants and young children caused by inappropriate insulin over-secretion.CHI is of heterogeneous aetiology with a significant genetic component and is often unresponsive to standard medical therapy options.The treatment of CHI Cord Trousers can b

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Tailoring by AgNPs of the Energetics of Charge Carriers in Electrically Insulating Polymers at the Electrode/Dielectric Contact

The ever increasing field of application of nanodielectrics in electrical insulations calls for description of the mechanisms underlying the performance of these systems and for identification of the signs exposing their aging under high Vegan Diet electric fields.Such approach is of particular interest to electrically insulating polymers because t

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